Roma are still goalless at the break against Qarabag, though Stephan El Shaarawy and Radja Nainggolan had the best chances.
Elsewhere, Chelsea and Atletico Madrid are still 0-0 at Stamford Bridge.
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The Giallorossi knew a victory would send them through to the Champions League Round of 16, while they could even win the group if Chelsea failed to beat Atletico Madrid at Stamford Bridge. Bruno Peres was suspended and Rick Karsdorp injured, but Radja Nainggolan and Diego Perotti returned from injury. The champions of Azerbaijan held Atleti to two draws in this group, but had Pedro Henrique and Rashad F Sadygov suspended, with Badavi Huseynov and Ansi Agolli injured.
The hosts pushed forward from the start, an Edin Dzeko back-heel flick smothered and Stephan El Shaarawy drew out the goalkeeper to turn it round him from a tight angle, forcing defenders to clear in front of an open goal.
Qarabag were occasionally dangerous on the counter, as Richard Almeida blasted over, but both Dzeko and Kostas Manolas went for the same free kick at the back post and got in the way.
On the stroke of half-time there was a double save from Ibrahim Sehic, who beat away the Nainggolan strike and then smothered the Aleksandar Kolarov follow-up.
Roma 0-0 Qarabag (Half-Time)
Roma: Alisson; Florenzi, Manolas, Fazio, Kolarov; Nainggolan, De Rossi, Strootman; El Shaarawy, Dzeko, Perotti
Qarabag: Sehic; Medvedev, Yunuszada, Rzezniczak, Guerrier; Ismaylov, Garayev, Almeida, Michel, Madatov; Ndlovu
Ref: Stieler (GER)
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