Roma make radical changes as they host troubled Torino, relying on Patrik Schick, Cengiz Under and Stephan El Shaarawy.
The match kicks off at 19:45 GMT – click here for a preview.
The Giallorossi got themselves right back in the running for a top-four spot and may well have transformed the Scudetto race with last week’s surprise 4-2 victory away to leaders Napoli.
Edin Dzeko bagged a brace in that game, but he is suspended here along with defender Federico Fazio, while Gregoire Defrel and Rick Karsdorp are injured.
It means Coach Eusebio Di Francesco looks to summer signing Schick, who is still seeking his first League goal in a Roma jersey.
He is supported by on-form Cengiz Under and the returning El Shaarawy, who has been pushed to the sidelines in recent weeks.
Juan Jesus steps in to the centre-back role to replace Fazio, but there is the temptation to rest players ahead of Tuesday’s Champions League showdown with Shakhtar Donetsk.
Torino have no more time to lose and Coach Walter Mazzarri is already under huge pressure following a string of poor results.
He had started so well after replacing Sinisa Mihajlovic, putting together three wins and two draws, but has now suffered humiliating back-to-back defeats against Juventus and Hellas Verona.
Nicolas Burdisso sits out a ban in defence against his former club, while Adem Ljajic, Lyanco, Joel Obi, Cristian Molinaro and Kevin Bonifazi are all injured.
M’Baye Niang can play with the aid of a protective mask after surgery this week on a fractured nose, suffered during a training ground accident.
It is becoming clear just how much the Granata relied on hitman Andrea Belotti last term and his injury problems have made life very difficult for his teammates.
This is a special game for Iago Falque, who is eager to impress his former club.
Perhaps the high point of Mihajlovic’s Toro tenure came back on December 20, when they beat Roma 2-1 at the Stadio Olimpico in the Coppa Italia.
Schick was on target, to date his only competitive goal in a Roma jersey, but Lorenzo De Silvestri and Simone Edera had already done the damage.
When these sides met in Serie A earlier this season, Aleksandar Kolarov’s free kick proved the only difference.
Walter Mazzarri has won only one of the last six meetings with Roma, 4-1 in January 2013 at the helm of Napoli, drawing two and losing three.
The tactician hasn’t beaten Roma at the Olimpico since February 2011, a 2-0 result for Napoli.
Eusebio Di Francesco has bad memories of Mazzarri, as his Sassuolo was crushed 7-0 by Inter in 2013-14 and 2014-15.
Roma: Alisson; Florenzi, Manolas, Juan Jesus, Kolarov; Nainggolan, De Rossi, Strootman; Cengiz, Schick, El Shaarawy
Subs: Jonathan, Peres, Capradossi, Lobont, Pellegrini, Gerson, Antonucci, Perotti, Gonalons, Skorupski
Torino: Sirigu; De Silvestri, Nkoulou, Moretti, Ansaldi; Rincon, Acquah; Falque, Baselli, Berenguer; Belotti
Subs: Milinkovic-Savic, Ichazo, Valdifiori, Niang, Edera, Barreca, Rivoira, Butic, Buongiorno
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