Gianluigi Donnarumma, Leonardo Spinazzola, Lorenzo Pellegrini and Andrea Belotti could start for Italy against England.
The friendly is at Wembley Stadium on Tuesday evening, following a 2-0 defeat to Argentina in Manchester.
Interim Coach Gigi Di Biagio is treating these games as an audition to keep the job long-term, especially with difficulties getting alternatives Carlo Ancelotti, Roberto Mancini or Antonio Conte.
Gigi Buffon was in goal against Argentina and made some important saves, but Milan shot-stopper Donnarumma is expected to take the gloves at Wembley.
Matteo Darmian of Manchester United is challenging Mattia De Sciglio for the role of right-back, with Atalanta’s Leonardo Spinazzola coming in on the left.
Roma midfielder Pellegrini could be given a chance, but Di Biagio is trying to get the pairing of Jorginho and Marco Verratti working, so uses them together once again.
Federico Chiesa was a surprise pick against Argentina, making his senior Italy debut at the age of 20, and the Fiorentina talent could be benched in favour of Inter veteran Antonio Candreva.
Lorenzo Insigne remains in his place, but Torino forward Belotti tries to rediscover some form and confidence in place of Ciro Immobile.
Italy (probable): Donnarumma; De Sciglio (Darmian), Bonucci, Rugani, Spinazzola; Pellegrini, Jorginho, Verratti; Chiesa (Candreva), Belotti, Insigne
See the latest Serie A predictions and betting tips with Eurotips.co.uk