Juventus and Milan go all-out, as the grudge match and Leonardo Bonucci’s first meeting with his old teammates is decisive for both clubs.
It kicks off at 19.45 UK time (18.45 GMT) at the Allianz Juventus Stadium in Turin.
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The Bianconeri went into the break for international duty with their lead at the top of the Serie A table sliced to just two points following a surprise stalemate with SPAL.
Max Allegri tries to ignore Tuesday’s upcoming Champions League quarter-final with Real Madrid and uses the strongest team at his disposal.
Some decisions are forced upon him, as Mario Mandzukic joins Alex Sandro and Federico Bernardeschi on the treatment table, but Juan Cuadrado is back on the bench for the first time since groin surgery.
Giorgio Chiellini pulled out of international duty with an injury, but is still thrown in from the start for a return to the old 3-5-2 formation, pushing Kwadwo Asamoah and Stephan Lichtsteiner into more advanced roles.
Medhi Benatia and Miralem Pjanic were always going to start, because they are both suspended against Real Madrid.
Douglas Costa is rested after impressing on international duty for Brazil, so Paulo Dybala supports Gonzalo Higuain.
Milan have won five Serie A games on the bounce to put them right in the thick of the race for a Champions League spot.
Ignazio Abate and Andrea Conti are out, but Davide Calabria and Alessio Romagnoli have shaken off injuries to bolster the defence.
Naturally, all eyes will be on Bonucci, as the stalwart of the old BBC defence returns to Turin for the first time since leaving Juventus. He missed the meeting at San Siro earlier this term, so it’s also his first encounter with his former teammates.
This is also a risky tactic, because both Bonucci and Lucas Biglia are one booking away from a ban and on Wednesday there’s the rescheduled Derby della Madonnina against Inter.
Andre Silva gets the nod rather than Patrick Cutrone or Nikola Kalinic in the trident attack, having broken his Serie A duck with two late winners in a row against Genoa and Chievo.
He is flanked by Suso and Hakan Calhanoglu.
Milan have lost their last six visits to Turin since a 1-0 result in March 2011, which was decided by a goal from Gennaro Gattuso. The Coach at the time was a certain Massimiliano Allegri.
Juventus: Buffon; Barzagli, Benatia, Chiellini; Lichtsteiner, Khedira, Pjanic, Matuidi, Asamoah; Dybala, Higuain
Juventus bench: Pinsoglio, Szczesny, De Sciglio, Cuadrado, Marchisio, Douglas Costa, Rugani, Sturaro, Bentancur
Milan: G Donnarumma; Calabria, Bonucci, Romagnoli, Rodriguez; Kessie, Biglia, Bonaventura; Suso, Andre Silva, Calhanoglu
Milan bench: A Donnarumma, Storari, Antonelli, Musacchio, Zapata, Locatelli, Mauri, Montolivo, Borini, Cutrone, Kalinic
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