Roma are without Javier Pastore, Diego Perotti, Justin Kluivert and Rick Karsdorp for the trip to Napoli.
It kicks off on Sunday at 19.30 UK time (18.30 GMT), click here for a match preview.
Alessandro Florenzi and Ante Coric have fully recovered after some issues in the wake of their 3-0 Champions League victory over CSKA Moscow.
Roma squad for Napoli: Olsen, Fuzato, Mirante; Luca Pellegrini, Juan Jesus, Marcano, Santon, Fazio, Kolarov, Florenzi, Manolas, Cristante, Lorenzo Pellegrini, De Rossi, Zaniolo, Nzonzi, Coric, Dzeko, Under, Schick, El Shaarawy
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