Roma have had to call up two youth team players to fill the gaps against Milan, as the squad is decimated.
It kicks off on Sunday at 19.30 GMT, click here for a match preview.
The entire first choice midfield is missing, as Steven Nzonzi and Bryan Cristante are suspended.
Daniele De Rossi returns from injury and is going to have to start with Lorenzo Pellegrini.
Cengiz Under, Diego Perotti and Juan Jesus are out of action, but Antonio Mirante is available again as second choice goalkeeper.
Coach Eusebio Di Francesco has called up 17-year-old youth team players Alessio Riccardi and Gianmarco Cangiano.
Roma squad for Milan: Olsen, Fuzato, Mirante, Karsdorp, Kolarov, Marcano, Santon, Fazio, Florenzi, Manolas; Lorenzo Pellegrini, De Rossi, Coric, Zaniolo, Pastore, Riccardi; Dzeko, Schick, Kluivert, Cangiano, El Shaarawy
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