Join us for all the build-up and action as it happens from the Frosinone-Lazio derby and high-flying Atalanta visiting Cagliari.
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We begin at the Stadio Benito Stirpe at 18.00 GMT, as Lazio have the opportunity to move into joint fifth place, only one shy of Milan in the Champions League berth.
However, it won’t be easy after they were forced to extra time and penalties in the Coppa Italia by Inter on Thursday, while Frosinone are fresh from a thumping 4-0 victory away to Bologna.
At 20.00 GMT, Atalanta hope to continue their amazing form after knocking Juventus out of the Coppa, as they visit a revamped Cagliari side.
The Bergamo Boys can also leap up to within a point of fourth place with a success in Sardinia and Duvan Zapata is only two goals off Cristiano Ronaldo in the Capocannoniere charts.
See the latest Serie A predictions and betting tips with Eurotips.co.uk