Roma make massive changes for their Europa League clash with CSKA Sofia, starting Carles Perez, Borja Mayoral and Chris Smalling.
It kicks off at 20.00 GMT, follow the build-up and action as it happens from this game, Milan-Sparta Prague and Real Sociedad-Napoli on the LIVEBLOG.
The Giallorossi won their opener with a comeback to beat Young Boys 2-1 in Switzerland last week and on Monday clawed Milan back for a 3-3 Serie A draw.
Coach Paulo Fonseca has to do without suspended Gianluca Mancini, with Amadou Diawara, Davide Santon, Javier Pastore, Riccardo Calafiori and Nicolò Zaniolo out of action.
The good news is the return finally of Smalling, who after the lengthy negotiations with Manchester United also picked up an injury, so this is his first appearance of the season.
There are changes elsewhere, with Pau Lopez taking the gloves, and rare starts for Gonzalo Villar, Carles Perez and Borja Mayoral.
CSKA Sofia were beaten 2-0 at home by CFR Cluj in their opening Europa League fixture.
Defender Jurgen Mattheij is the only real absentee for the Bulgarians in Rome, who rely on Gambian centre-forward Ali Sowe.
They also have some Italians in the squad, such as goalkeeper Gustavo Busatto and midfielder Stefano Beltrame.
Roma: Pau Lopez; Fazio, Smalling, Kumbulla; Bruno Peres, Villar, Cristante, Spinazzola; Carles Perez, Mkhitaryan; Borja Mayoral
Roma bench: Boer, Mirante, Karsdorp, Ibanez, Juan Jesus, Pellegrini, Dzeko, Pedro, Veretout, Zalewski, Milanese
CSKA Sofia: Busatto; Vion, Antov, Zanev, Mazikou; Youga, Geferson; Sankharé; Sinclair, Sowe, Yomov
CSKA Sofia bench: Evtimov, Henrique, Carey, Beltrame, Keita, Panaranda, Tutitsov, Tiago Rodrigues, Ahmedov, Galabov
Ref: Kulbakov (BLR)