Roma and Young Boys go head-to-head for the top spot in their Europa League group, but already qualified for the Round of 32.
It kicks off at 20.00 GMT, follow all the build-up and action as it happens from this game, Celtic-Milan and AZ Alkmaar-Napoli on the LIVEBLOG.
The Giallorossi rest Edin Dzeko, Henrikh Mhitaryan, Leonardo Pellegrini and Leonardo Spinazzola, while Marash Kumbulla is back on the bench after his COVID all-clear.
Bryan Cristante is again used as a centre-back, but youth team product Riccardo Calafiori gets a start on the left wing.
Carles Perez and Pedro Rodriguez support Borja Mayoral in a very Spanish attack.
Roma are top of the group on 10 points, with Young Boys on seven, and Cluj follow with four.
Roma: Pau Lopez; Ibanez, Cristante, Juan Jesus; Bruno Peres, Villar, Diawara, Calafiori; Carles Perez, Pedro; Borja Mayoral
Roma bench: Berti, Mirante, Karsdorp, Pellegrini, Dzeko, Fazio, Kumbulla, Spinazzola, Bove, Ciervo, Milanese, Mkhitaryan
Young Boys: Von Ballmoos; Hefti, Camara, Zesiger, Lefort; Rieder, Aebischer, Garcia; Fassnacht, Nsame, Ngamaleu
Young Boys bench: Neuenschwander, Faivre, Sierro, Sulejmani, Gaudino, Burgy, Elia, Siebatcheu, Mambimbi, Maier, Maceiras
Ref: Jovic (CRO)