Roma and Juventus meet in Foxborough in a pre-Serie A showdown with Juan Cuadrado and Mattia De Sciglio starting against Aleksandar Kolarov and Gregoire Defrel.
The International Champions Cup tie kicks off in Massachusetts at 21.05 UK time (20.05 GMT).
Serie A begins on the weekend of August 20 and these teams finished in the top two last term.
Douglas Costa was the biggest summer signing for Juve and had been expected to receive his first start, but instead Cuadrado gets the nod, partnering Paulo Dybala and Mario Mandzukic behind Gonzalo Higuain.
Former Milan full-back De Sciglio also starts with ex-Roma men Medhi Benatia and Miralem Pjanic.
Eusebio Di Francesco is implementing his traditional 4-3-3 formation with the Giallorossi, who beat Tottenham Hotspur 3-2 last time out.
Daniele De Rossi is chosen ahead of Maxime Gonalons, while Kolarov and Gregoire Defrel are in the starting XI with Diego Perotti and last year’s Capocannoniere Edin Dzeko.
However, Kostas Manolas, Emerson Palmieri and Alessandro Florenzi are injured.
So far in this tournament, Roma have beaten Tottenham 3-2 and were held 1-1 by Paris Saint-Germain.
Juventus lost 2-1 to Barcelona and defeated PSG 3-2.
Roma: Alisson; Peres, Fazio, Juan Jesus, Kolarov; Nainggolan, De Rossi, Strootman; Defrel, Dzeko, Perotti
Roma bench: Skorupski, Lobont, Romagnoli, Nura, Moreno, Castan, Gonalons, Gerson, Pellegrini, Cengiz Under, Iturbe, Sadiq, Tumminello, Antonucci, Keba
Juventus: Buffon; De Sciglio, Benatia, Rugani, Alex Sandro; Pjanic, Marchisio; Cuadrado, Dybala, Mandzukic; Higuain
Juventus bench: Pinsoglio, Del Favero, Asamoah, Lichtsteiner, Chiellini, Sturaro, Lemina, Khedira, Rincon, Caligara, Coccolo, Vogliacco, Mandragora, Bernardeschi, Kean, Bentancur, Douglas Costa