Lorenzo Pellegrini and Javier Pastore are back in the Roma squad to face Fiorentina, but Kostas Manolas is suspended.
It kicks off on Wednesday at 20.00 UK time, click here for a match preview.
Coach Claudio Ranieri will be able to count on Pellegrini and Pastore for the first time since he took over from Eusebio Di Francesco.
However, Manolas is suspended, with Alessandro Florenzi and Stephan El Shaarawy still out injured.
Roma squad for Fiorentina: Olsen, Mirante, Fuzato; Karsdorp, Jesus, Kolarov, Fazio, Marcano, Santon; Cristante, Pellegrini, De Rossi, Nzonzi, Riccardi, Pastore, Coric, Zaniolo; Dzeko, Kluivert, Schick, Perotti, Under
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