Inter pick Lautaro Martinez and Borja Valero against Rodrigo De Paul’s Udinese, who are desperate for points to avoid the drop.
It kicks off at the Dacia Arena at 19.30 UK time (18.30 GMT).
You can follow all the build-up and action as it happens from this game and Chievo-SPAL on the LIVEBLOG.
Both sides are highly-motivated, as Inter have not yet mathematically secured their place in the Champions League for next season, while Udinese hover four points above Empoli and the relegation zone.
The Friulani have certainly improved under Coach Igor Tudor, but are dealing with an injury crisis that has ruled out William Troost-Ekong, Nicolas Opoku, Seko Fofana, Valon Behrami, Antonin Barak and the suspended Samir.
Bram Nuytinck therefore returns from injury to bolster the defence, while De Paul is again placed in midfield to pull the strings behind Kevin Lasagna and Ignacio Pussetto, benching Stefano Okaka.
Inter are missing Matias Vecino, who picked up an injury in training yesterday, so Borja Valero steps in to midfield alongside Marcelo Brozovic rather than Roberto Gagliardini.
Radja Nainggolan is eager to make an impact on his birthday, especially after last week’s scorching volley against Juventus, joined by Matteo Politano and Ivan Perisic.
The role of centre-forward this time goes to Lautaro Martinez, leaving Mauro Icardi on the bench after his latest controversy involving a nude photoshoot with his wife and agent Wanda Nara.
Udinese: Musso; Stryger-Larsen, De Maio, Nuytinck; D’Alessandro, Mandragora, Sandro, De Paul, Zeegelaar; Pussetto, Lasagna
Inter: Handanovic; D’Ambrosio, De Vrij, Skriniar, Asamoah; Borja Valero, Brozovic; Politano, Nainggolan, Perisic; Lautaro Martinez
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