Stefano Pioli has accepted the Sampdoria job, with Marco Giampaolo heading to Milan, claim multiple sources.
Sky Sport Italia and Sportitalia have the same version of events, pointing to a successful meeting between Pioli and Samp representatives.
He would be back in action just weeks after he resigned from Fiorentina in protest at criticism from the club.
Eusebio Di Francesco was another candidate for Sampdoria, but is still under contract with Roma and needs to terminate that deal by mutual consent first.
As for the current Blucerchiati boss, it is now practically certain that Giampaolo will take over at Milan, with an announcement expected as early as Monday.
The only wait is for Paolo Maldini to be confirmed as the new technical director, as he gave his backing to the Giampaolo option.
Their first choice had been Maurizio Sarri, but Giampaolo has a similar approach to the game and replaced Sarri at Empoli four years ago.