Roma have their first game since March 1 with Carles Perez, Henrikh Mkhitaryan, Javier Pastore and debutant Roger Ibanez against Manolo Gabbiadini’s Sampdoria.
It kicks off at 20.45 UK time (19.45 GMT), you can follow the build-up and action as it happens from this game, Inter-Sassuolo and Atalanta-Lazio on the LIVEBLOG.
Paulo Fonseca is trying to ignore the usual off the field drama, with director of sport Gianluca Petrachi suspended by his club and another takeover bid collapsing.
Goalkeeper Pau Lopez suffered a microfracture in his wrist straight after resuming training, so he is still out of action along with Nicolò Zaniolo, Davide Santon, Juan Jesus and Mert Cetin.
Veteran Antonio Mirante takes over the gloves, while Carles Perez, Mkhitaryan and surprisingly Pastore are chosen to fan out behind Dzeko, leaving Lorenzo Pellegrini, Cengiz Under, Justin Kluivert and Bryan Cristante on the bench.
The biggest shock is in defence, where Gianluca Mancini is not 100 per cent fit, but Roger Ibanez is thrown into the starting XI for his Roma and Serie A debut.
He arrived on loan from Atalanta in January, having made on substitute Champions League appearance.
Sampdoria already played at the weekend and were beaten 2-1 by Inter at San Siro.
Fabio Quagliarella is still unavailable due to injury along with Alex Ferrari, but ex-Roma coach Claudio Ranieri makes changes.
Manolo Gabbiadini and Federico Bonazzoli take over in attack from Gaston Ramirez and Antonino La Gumina, while Albin Ekdal and Ronaldo Vieira also join the fray.
The Blucerchiati are under increasing pressure, hovering just above the drop zone.
Roma: Mirante; Bruno Peres, Smalling, Ibanez, Kolarov; Diawara, Veretout; Carles Perez, Pastore, Mkhitaryan; Dzeko
Sampdoria: Audero; Bereszynski, Yoshida, Tonelli, Augello; Depaoli, Thorsby, Ekdal, Linetty, Jankto; Gabbiadini
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