Roma have largely dominated the game so far, but needed Borja Mayoral to cancel out the Young Boys opener on a long ball.
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The Giallorossi had already qualified for the knockouts, so could rotate their squad in this head-to-head for top spot.
Riccardo Calafiori immediately had a half-volley flash just wide, then Bruno Peres saw his free kick fingertipped over the bar.
Pedro floated a great pass for Carles Perez, whose first touch was excellent, but the angled drive flashed off target. Pedro then went for it himself, forcing a save from a tricky angle.
However, Young Boys took the lead with their first shot on goal and it was route one stuff. A long ball over the top allowed Nsame to sprint past Bryan Cristante and beat Pau Lopez.
Calafiori impressed again, completing a give-and-go to test the goalkeeper from a tight angle.
Roma got their equaliser moments later, as Pedro forced an astonishing save from six yards and Borja Mayoral could not miss the rebound.
Roma 1-1 Young Boys (Half-Time)
Nsame 34 (Y), Borja Mayoral 43 (R)
Roma: Pau Lopez; Ibanez, Cristante, Juan Jesus; Bruno Peres, Villar, Diawara, Calafiori; Carles Perez, Pedro; Borja Mayoral
Young Boys: Von Ballmoos; Hefti, Camara, Zesiger, Lefort; Rieder, Aebischer, Garcia; Fassnacht, Nsame, Ngamaleu
Ref: Jovic (CRO)