Marash Kumbulla admits the Coppa Italia ‘is an important objective’ for Roma, so they need to get past Spezia.
It kicks off at 20.15 GMT, click here for the line-ups.
This is the first match for the Giallorossi since their humiliating 3-0 Derby d’Italia defeat to Lazio.
“There’s not much we can say. We have to forget about that game and certainly do better, starting from this evening,” centre-back Kumbulla told Roma TV.
“The Coppa Italia is an important objective for us. We need to have a better attitude than the one we showed against Lazio.”
The winners of this Round of 16 tie will go on to face Napoli in the quarter-final.