Roma are forced to completely reinvent their defence with Leonardo Spinazzola as a centre-back with Federico Fazio against Benevento.
It kicks off at 19.45 GMT, you can follow the build-up and action as it happens on the LIVEBLOG.
The Giallorossi are fresh from Thursday’s impressive 2-0 Europa League victory away to Sporting Braga, but have a massive injury crisis to deal with, particularly in defence.
Chris Smalling, Marash Kumbulla, Roger Ibanez, Bryan Cristante, Davide Santon and Riccardo Calafiori are all out of action.
January buy Bryan Reynolds is still in America due to red tape issues, so the only option is to bring Fazio back from cold storage where he has been frozen out for weeks, and move wing-back Spinazzola into the central three.
Edin Dzeko scored against Braga midweek, but is dropped again for Borja Mayoral, supported by Lorenzo Pellegrini and Henrikh Mkhitaryan.
Benevento are in need of a boost after sliding down the standings lately, but at least they have almost a full squad at their disposal now, missing only Gaetano Letizia.
Gianluca Lapadula leads the attack with support from Artur Ionita and Gianluca Caprari.
Benevento: Montipò; Depaoli, Glik, Barba, Foulon; Hetemaj, Schiattarella, Viola; Ionita, Caprari; Lapadula
Roma: Pau Lopez; Fazio, Mancini, Spinazzola; Karsdorp, Villar, Veretout, Bruno Peres; Pellegrini, Mkhitaryan; Borja Mayoral