Roma give Stephan El Shaarawy his first start since returning to the club, supporting Edin Dzeko with a makeshift defence against Sporting Braga.
It kicks off at 20.00 GMT, you can follow the build-up and action as it happens on the LIVEBLOG.
The Giallorossi are in a very strong position to reach the Round of 16, having won the first leg 2-0 in Portugal.
However, coach Paulo Fonseca doesn’t have much scope for squad rotation, as the injury list remains extensive, including Chris Smalling, Roger Ibanez and Davide Santon.
El Shaarawy gets his first start since returning to Roma, supporting Dzeko and Pedro, while they change tactics to four at the back so Leonardo Spinazzola can rest.
Braga aren’t exactly full-strength either, as Ricardo Esgaio is suspended, with Andre Castro, Rui Fonte, Francisco Moura, David Carmo and Iuri Medeiros injured.
Roma: Pau Lopez; Karsdorp, Mancini, Cristante, Bruno Peres; Diawara, Villar, Veretout; El Shaarawy, Pedro; Dzeko
Roma bench: Mirante, Fuzato, Pellegrini, Mayoral, Perez, Spinazzola, Ciervo, Darboe, Tripi, Mkhitaryan
Braga: Tiago Sa; Ze Carlos, Vitor Tormena, Rolando, Nuno Sequeira; Piazon, Novais, Gaitain; Galeno, Sporar, Andre Horta
Braga bench: Matheus, Santos, Al Musrati, Ruiz, Ricardo Horta, Cristian Borja, Fransergio, Infande, Bruno Rodrigues, Vitor Oliveira
Ref: Ekberg (SWE)