German official Felix Brych will officiate Milan’s Europa League clash with Manchester United, while Antonio Mateu Lahoz takes Shakhtar Donetsk-Roma.
The second leg of the Europa League Round of 16 will be played on Thursday evening.
Milan drew the first leg 1-1 at Old Trafford and can in theory go through with a goalless draw, on away goals.
Brych has been assigned to this fixture, assisted by Marco Fritz in the VAR booth.
Milan are unbeaten with the 45-year-old German, managing one win and three draws.
When it comes to Italian teams, Brych oversaw 11 wins, eight draws and six defeats.
His record with Manchester United is three victories, three stalemates and two losses, but the last two have both been defeats to Barcelona and Sevilla.
Brych has overseen 16 English wins, nine draws and 12 defeats.
Roma won the first leg of their tie with Shakhtar Donetsk 3-0 at the Stadio Olimpico.
The referee in Ukraine will be Spain’s Antonio Mateu Lahoz, with Alejandro Hernandez as his VAR.